SINGLE-CELL TRANSCRIPTOMICS OF POPLITEAL LYMPHATIC VESSELS AND PERIPHERAL VEINS REVEALS ALTERED LYMPHATIC MUSCLE AND IMMUNE CELL POPULATIONS IN THE TNF-TG ARTHRITIS MODEL

Abstract Background Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients.While joint-draining TNF-Tg popliteal lymphatic vessels (PLVs) have deficits in contractility during end-stage arthritis, the nature of lymphatic muscle cells (LMCs) and their TNF-altered transcriptome remain unk

Cortical spreading depression (CSD) is closely associated with important pathologies including stroke, seizures and migraine.The mechanisms underlying SD in its various forms are still incompletely understood.Here we describe SD-like events in an invertebrate model, the ventilatory central pattern generator (CPG) of locusts.Using K(+) -sensitive mi

Piscirickettsiosis, the cause of great losses in Chilean salmonid population, is produced by Piscirickettsia salmonis.The bacterium has developed resistance to treatments over time, including antibiotics and vaccines, due to a variety of evasive strategies, including biofilm formation.The bacterium has genomic islands, clusters of Vinyl Record Clea

Antimicrobial resistance is one of the largest threats to global health and imposes substantial burdens in terms of morbidity, mortality, and economic costs.The Work Socks gut is a key conduit for the genesis and spread of antimicrobial resistance in enteric bacterial pathogens.Distinct bacterial species that cause enteric disease can exist as inva

Clinicians are often very sceptical about applying automatic image processing approaches, especially deep learning-based methods, in practice.One main reason for this is the black-box nature of these approaches and the inherent problem of missing insights of the automatically derived decisions.In order to increase trust in these methods, this paper